Contributor(s)NEW YORK UNIV MEDICAL CENTER NY
KeywordsMedicine and Medical Research
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AbstractThis project will test the basic hypothesis that a given microsatellite marker allele occurs with greater frequency among the individuals affected with prostate cancer than among the controls. These studies will take advantage of the fact that two populations of Ashkenazi Jewish men are readily available for a case- control study. The first is a group of men at high heritable risk based on their having early-onset prostate cancer. The second is a group of men at low heritable risk who have no personal or family history of prostate cancer. Thus, we expect to observe predisposition alleles in the men at high risk that are not present in the men at low risk. The predisposition genes are likely to be within chromosomal regions in which loss of heterozygosity has occurred. Because these regions have remained identical by descent since the high-risk mutations occurred, they can be recognized by the presence of specific alleles of microsatellite markers in the high-risk group that are not present in the low-risk group.