EFFECTS OF LIDOCAINE INJECTIONS INTO THE LATERAL PARABRACHIAL NUCLEUS ON DIPSOGENIC AND PRESSER RESPONSES TO CENTRAL ANGIOTENSIN-II IN RATS
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Universidade Estadual Paulista (UNESP)Keywords
LATERAL PARABRACHIAL NUCLEUSANGIOTENSIN II
WATER INTAKE
ARTERIAL PRESSURE
THIRST
LOCAL ANESTHETIC
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http://hdl.handle.net/11449/35543http://acervodigital.unesp.br/handle/11449/35543
https://dx.doi.org/10.1016/0006-8993(95)00872-N
Abstract
This study investigated the effects of bilateral injections of the local anesthetic, lidocaine, into the lateral parabrachial nucleus (LPBN) on the dipsogenic and presser responses induced by intracerebroventricular (i.c.v.) injection of angiotensin II (ANG II). Centrally injected ANG II (50 ng/l mu l) induced water intake (10.2 +/- 0.8 ml/h) and presser responses (22 +/- 1 mmHg). Prior bilateral injection of 10% lidocaine (200 nl) into the LPBN increased the water intake (14.2 +/- 1.4 ml/h), but did not change the presser response (17 +/- 1 mmHg) to i.c.v. ANG II. Lidocaine alone injected into the LPBN also induced a presser response (23 +/- 3 mmHg). These results showing that bilateral LPBN injection of lidocaine increase water intake induced by i.c.v. ANG II are consistent with electrolytic and neurotoxic lesion studies and suggest that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II. These results also provide evidence that it is feasible to reversibly anesthetize this brain area to facilitate fluid-related ingestive behavior.Date
2014-05-20Type
outroIdentifier
oai:acervodigital.unesp.br:11449/35543Brain Research. Amsterdam: Elsevier B.V., v. 695, n. 2, p. 250-252, 1995.
0006-8993
http://hdl.handle.net/11449/35543
http://acervodigital.unesp.br/handle/11449/35543
10.1016/0006-8993(95)00872-N
WOS:A1995TA39000021
http://dx.doi.org/10.1016/0006-8993(95)00872-N