Adult intussusception: 14 case reports and their outcomes Intususcepción en el adulto: Revisión de 14 casos y su seguimiento
Author(s)M. P. Guillén-Paredes
J. G. Martín-Lorenzo
J. A. Torralba-Martínez
M. J. Cases-Baldó
J. L. Aguayo-Albasini
Invaginación intestinal adulto
Adult intestinal invagination
Diseases of the digestive system. Gastroenterology
Specialties of internal medicine
MetadataPerlihat publikasi penuh
AbstractAims: to analyze diagnostic and therapeutic options depending on the clinical symptoms, location, and lesions associated with intussusception, together with their follow-up and complications. Patients and methods: patients admitted to the Morales Meseguer General University Hospital (Murcia) between January 1995 and January 2009, and diagnosed with intestinal invagination. Data related to demographic and clinical features, complementary explorations, presumptive diagnosis, treatment, follow-up, and complications were collected. Results: there were 14 patients (7 males and 7 females; mean age: 41.9 years-range: 17-77) who presented with abdominal pain. The most reliable diagnostic technique was computed tomography (8 diagnoses from 10 CT scans). A preoperative diagnosis was established in 12 cases. Invaginations were ileocolic in 8 cases (the most common), enteric in 5, and colocolic in 2 (coexistence of 2 lesions in one patient). The etiology of these intussusceptions was idiopathic or secondary to a lesion acting as the lead point for invagination. Depending on the nature of this lead point, the cause of the enteric intussusceptions was benign in 3 cases and malignant in 2. Ileocolic invaginations were divided equally (4 benign and 4 malignant), and colocolic lesions were benign (2 cases). Conservative treatment was implemented for 4 patients and surgery for 10 (7 in emergency). Five right hemicolectomies, 3 small-bowel resections, 2 left hemicolectomies, and 1 ileocecal resection were performed. Surgical complications: 3 minor and 1 major (with malignant etiology and subsequent death). The lesion disappeared after 3 days to 6 weeks in patients with conservative management. Mean follow-up was 28.25 months (range: 5-72 months). Conclusions: a suitable imaging technique, preferably CT, is important for the diagnosis of intussusception. Surgery is usually necessary but we favor conservative treatment in selected cases.<br>Objetivos: analizar las opciones terapéuticas en función de la clínica, localización y lesión asociada a la intususcepción, así como, su seguimiento y complicaciones. Pacientes y métodos: pacientes ingresados en el HGU Morales Meseguer (Murcia) desde enero de 1995 hasta enero 2009, con diagnóstico de invaginación intestinal. Se recogieron datos demográficos, clínicos, exploraciones complementarias, diagnóstico presuntivo, tratamiento, seguimiento y complicaciones. Resultados: 14 pacientes (edad media 41,9 años, rango: 17-77), 7 varones y 7 mujeres, que debutaron principalmente con dolor abdominal. La exploración más fiable en el diagnóstico fue la tomografía computerizada, TC (8 diagnósticos, de 10 exploraciones). El diagnóstico preoperatorio se obtuvo en 12 casos, encontrando, invaginaciones ileocólicas en 8 casos (las más frecuentes), entéricas en 5 casos y colocólicas en 2, teniendo en cuenta que son 14 los pacientes y 15 las lesiones debido a la coexistencia de 2 invaginaciones en un mismo sujeto. La etiología de las intususcepciones es idiopática o secundaria a una lesión que hace de cabeza de invaginación. Según la naturaleza de dichas lesiones la causa de intususcepciones entéricas fue benigna en 3 casos y maligna en 2. De las ileocólicas, se repartieron equitativamente (4 benignas y 4 malignas); y de las colocólicas, sus lesiones fueron benignas (2 casos). Se realizó tratamiento conservador en 4 pacientes y quirúrgico en 10 (7 urgente). Con 5 hemicolectomías derechas, 3 resecciones de intestino delgado, 2 hemicolectomías izquierdas y una resección ileocecal. Las complicaciones quirúrgicas: 3 menores y 1 mayor (de etiología maligna y consecuente exitus). En los pacientes con manejo conservador desapareció la lesión entre 3 días y 6 semanas. Se siguieron durante 28,25 meses de media (rango 5-72 meses). Conclusiones: para diagnosticar las intususcepciones es importante una adecuada técnica de imagen, recomendablemente TC. Abogamos por un tratamiento conservador en aquellos casos donde no se encuentre etiología de invaginación, según el tipo de intususcepción y clínica, siempre asociado a seguimiento.
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The Effect of Using Sewerage System on Incidence of Acute Diarrhoea on Children under Five Years Old in Bandar-Anzali City in Guilan Province in 2009-Phase IMorteza Fallah-Karkan; Hannan Ebrahimi; Zahra Akbarian; Seyyede Zohreh Banihashemi; Maryam Rostamnejad; Matin Daneshyari; Elahe Sayyarifard2; Kaveh Marzbani; Haleh Ahmadnia; Javad Moazzami-Sahzabi; et al. (Iranian Society for Infectious Diseases and Tropical Medicine, 2013-07-01)Backgroun and objective:The scarce water resources and Poor quality drinking water with the lack of a proper sewage collection and disposal system and increasing management problems due to rapid population growth made Islamic Republic of Iran to pay priority attention to the water and sewerage problems of districts in its five-year development plan. In this regard, water and sewerage project in Bandar Anzali became a priority by Guilan province Urban Water and Sewerage Company with the government partnership and World Bank financial support. The objective of this study is to complete the first phase of a two-phase study to determine the impact of using an urban sewerage system on acute Diarrhoea in children under five years of age in Bandar-Anzali in the Guilan province.Materails and methods: The study is a concurrent control before and after field trial which is carried out in two stages: before (phase I) and after (phase II). Sampling for phase I was performed in the middle month of each season, November and February 2009 and May and August 2010. The incidence of acute Diarrhoea was measured with the participation of 2400 mothers of children under 5 years old in the city of Bandar-Anzali in two groups: the intervention group (inside the sewerage system project perimeters) and the control group (outside the project perimeters). Data were collected by local female general practitioners and medical students in each city, under supervision of the community medicine department and by door-to-door interview with mothers. Data were analyzed using the SPSS 11.5 software package and the Pearson Chi-Square was used to compare qualitative variables between groups, and the t-test and One-Way ANOVA was used to compare quantitative variables.Results: The annual incidence of acute diarrhoea in children under five years old was 11.9%. The seasonal pattern of acut diarrheoa incidence was 12.6% in May, 13.3 in August, 11.5% in November, and 10.3% in February respectively. The highest incidence of acute diarrhoea was seen in children from 2 to 5 years of age.Conclusion: The study showed the incidence of acute diarrhoea on children under five years old in Bandar-Anzali city is moderate and it follows a seasonal pattern. The highest rate was seen in summer and the lowest rate in winter. It is expected to decrease with the initiation of the sewerage system program.
Clinical Features, Presence of Human Herpesvirus-8 and Treatment Results in Classic Kaposi SarcomaÖzlem Su; Nahide Onsun; Hande Arda; Ömer Ümmetoğlu; Ayşe Pekdemir (Galenos Yayincilik, 2008-12-01)Background and Design: Classic Kaposi sarcoma (KS) occurs predominantly among the elderly, with Jews, Italians and Greeks. Classic KS has been seen relatively frequently in Turkey. Our aim was to evaluate the demographic, clinical features of Kaposi sarcoma and etiopathological role of human herpesvirus-8 (HHV-8). Treatment results of 18 classic Kaposi’s sarcoma were also concluded.Material and Method: Eighteen cases of classic Kaposi sarcoma diagnosed as clinically and histopathologically between January 2001 and August 2008 in our dermatology department were taken to this study. Demographic, clinical features and treatment results were reviewed retrospectively in all patients. HHV-8 was investigated in the lesional skin of 7 patients.Results: A male/female ratio of 2/1 was found. Mean age at diagnosis was 67.2 (37-94) years. Bilaterally lower extremities were involved in 15 patients (83.3%), the trunk was involved in 3 patients (16.6%). Plaques and nodules were the common type of lesions (66.6% and 55.5%). Nine patients had no symptoms (50%). Edema was the most common symptom (38.8%). A second primary malignancy was found in 2 patients (11.1%). HHV-8 was detected in 6 of the 7 patients(85.7%). Majority of the patients were treated with interferon alfa (subcutaneously) and cryotherapy as a monotherapy or a combination therapy. Imiquimod was the second agent in combined treatment (27.7%). Conclusion: We suggest that interferon alfa and imiquimod can be used as first line therapy agents with their antiviral and immunmodulatuar features in the treatment of KKS. (Turkderm 2008; 42: 122-6)
Combination therapies, effectiveness, and adherence in patients with HIV infection: clinical utility of a single tablet of emtricitabine, rilpivirine, and tenofovirWainberg MA (Dove Press, 2013-02-01)Mark A WainbergMcGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, CanadaAbstract: A recent addition to the anti-human immunodeficiency virus armamentarium of drugs is rilpivirine, which is a potent non-nucleoside reverse transcriptase inhibitor. This review focuses on the clinical utility of rilpivirine in terms of efficacy and virologic suppression, drug resistance, drug-drug interactions, and safety. The rilpivirine-tenofovir-emtricitabine combination is a safe and effective regimen for use in most patients who are ready to start first-line anti-human immunodeficiency virus therapy. Although drug resistance can be a problem in patients who initiate therapy on rilpivirine-based regimens with viral loads &amp;gt; 100,000 copies of viral RNA/mL, this problem can be alleviated by first starting therapy with efavirenz-tenofovir-emtricitabine for several months to suppress viral load to &amp;lt;50 copies/mL before switching to rilpivirine-based therapy. E138K is the most important mutation associated with resistance against rilpivirine and its development must be avoided whenever possible, because this mutation confers broad cross-resistance against all approved members of the non-nucleoside reverse transcriptase inhibitor family of drugs.Keywords: non-nucleoside reverse transcriptase inhibitors, rilpivirine, human immunodeficiency virus, treatment, resistance