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The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational Studies

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Author(s)
Behzad Hajarizadeh
Behnam Sadeghirad
Ali-Akbar Haghdoost
Ali Mirzazadeh
Keywords
Epidemiologic studies
Mental health
Systematic review
Meta-analysis
Psychiatry
RC435-571
Neurology. Diseases of the nervous system
RC346-429
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Internal medicine
RC31-1245
Medicine
R
DOAJ:Psychiatry
DOAJ:Medicine (General)
DOAJ:Health Sciences
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URI
http://hdl.handle.net/20.500.12424/1526808
Online Access
https://doaj.org/article/dac626e8fb9548b680021b6cf171d44d
Abstract
"n "n "nAbstract: "nIn contrast to traditional reviews, systematic reviews explore theliterature on a specific topic comprehensively using a well-defined protocol and recruit the findings of eligible studies after the assessment of their qualities, using a clear and reproducible method. Checking the assumptions, we may merge the findings of recruited studies in a systematic review and use metaanalysis techniques not only to estimate the pooled effect but also to assess the possible sources of heterogeneity and the extend of heterogeneity in the findings . Generally, randomized clinical trials are the most common type of studies which are recruiting in systematic reviews and meta-analyses. However, we couldn't ignore the importance of observational studies particularly in sensitivity topics with ethical limitations against interventional studies. Although we are usually faced with wide variations in the methodology of observational studies even in narrow topics, systematic review and meta-analysis of their results can generate valuable findings. They are particularly useful for explaining the source of heterogeneity in the results of primary observational studies .In this paper, we review the basic concepts of the systematic review and metaanalysis and their main applications in summarizing the findings of observational studies with respect to their advantages and limitations.
Date
2007-12-01
Type
Article
Identifier
oai:doaj.org/article:dac626e8fb9548b680021b6cf171d44d
1735-4587
2008-2215
https://doaj.org/article/dac626e8fb9548b680021b6cf171d44d
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