Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study
Author(s)
Colombini, Bella L.Modena, Karin C.S.
Calvo, Adriana M.
Sakai, Vivien T.
Giglio, Fernando P. M.
Dionísio, Thiago J.
Trindade Jr., Alceu S.
Lauris, José R. P.
Santos, Carlos F.
Contributor(s)
Universidade Estadual Paulista (UNESP)Keywords
articainelocal anesthetic agent
mepivacaine
nonsteroid antiinflammatory agent
piroxicam
adolescent
adult
clinical trial
controlled clinical trial
controlled study
crossover procedure
dental anesthesia
double blind procedure
female
human
local anesthesia
male
methodology
molar tooth
postoperative pain
randomized controlled trial
tooth disease
tooth extraction
Adolescent
Adult
Anesthesia, Dental
Anesthesia, Local
Anesthetics, Local
Anti-Inflammatory Agents, Non-Steroidal
Carticaine
Cross-Over Studies
Double-Blind Method
Female
Humans
Male
Mepivacaine
Molar, Third
Pain, Postoperative
Piroxicam
Tooth Extraction
Tooth, Impacted
Full record
Show full item recordAbstract
Objective: Comparison of the clinical efficacy of 4% articaine in relation to 2% mepivacaine, both with 1:100,000 epinephrine, in the prevention of postoperative pain after lower third molar removal. Study design: Twenty patients underwent removal of bilateral lower third molars under local anesthesia (articaine or mepivacaine) in 2 separate appointments, in a double-blind, randomized, and crossed manner. Objective and subjective parameters were recorded for paired comparison of postoperative courses. Results: Duration of analgesia provided by articaine and mepivacaine was 198.00 ± 25.86, and 125.40 ± 13.96 min, respectively (P = .02), whereas the duration of anesthesia was 273.80 ± 15.94 and 216.85 ± 20.15 min, respectively (P = .06). Both solutions exerted no important effects upon arterial pressure, heart rate, or oxygen saturation (P > .05). Conclusions: Articaine provides a longer period of analgesic effect and a tendency for a longer period of anesthesia as compared to mepivacaine. The presence of a vasoconstrictor agent in local anesthetic solutions does not seem to influence hemodynamic parameters during lower third molar removal in healthy subjects. © 2006 Mosby, Inc. All rights reserved.Date
2014-05-27Type
info:eu-repo/semantics/articleIdentifier
oai:repositorio.unesp.br:11449/69014http://dx.doi.org/10.1016/j.tripleo.2005.09.003
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, v. 102, n. 2, p. 169-174, 2006.
1079-2104
http://hdl.handle.net/11449/69014
10.1016/j.tripleo.2005.09.003
2-s2.0-33746225379
Copyright/License
closedAccessCollections
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Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover studyUniversidade Estadual Paulista (UNESP); Colombini, Bella L.; Modena, Karin C.S.; Calvo, Adriana M.; Sakai, Vivien T.; Giglio, Fernando P. M.; Dionísio, Thiago J.; Trindade Jr., Alceu S.; Lauris, José R. P.; Santos, Carlos F. (2014-05-27)Objective: Comparison of the clinical efficacy of 4% articaine in relation to 2% mepivacaine, both with 1:100,000 epinephrine, in the prevention of postoperative pain after lower third molar removal. Study design: Twenty patients underwent removal of bilateral lower third molars under local anesthesia (articaine or mepivacaine) in 2 separate appointments, in a double-blind, randomized, and crossed manner. Objective and subjective parameters were recorded for paired comparison of postoperative courses. Results: Duration of analgesia provided by articaine and mepivacaine was 198.00 ± 25.86, and 125.40 ± 13.96 min, respectively (P = .02), whereas the duration of anesthesia was 273.80 ± 15.94 and 216.85 ± 20.15 min, respectively (P = .06). Both solutions exerted no important effects upon arterial pressure, heart rate, or oxygen saturation (P > .05). Conclusions: Articaine provides a longer period of analgesic effect and a tendency for a longer period of anesthesia as compared to mepivacaine. The presence of a vasoconstrictor agent in local anesthetic solutions does not seem to influence hemodynamic parameters during lower third molar removal in healthy subjects. © 2006 Mosby, Inc. All rights reserved.
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