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dc.contributor.authorDavern, PJ
dc.contributor.authorMcKinley, MJ
dc.date.accessioned2019-10-26T23:26:02Z
dc.date.available2019-10-26T23:26:02Z
dc.date.created2018-03-01 00:05
dc.date.issued2014-08-22
dc.identifieroai:minerva-access.unimelb.edu.au:11343/41845
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000325836000036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifierDavern, PJ; McKinley, MJ, BRAIN REGIONS INFLUENCED BY THE LATERAL PARABRACHIAL NUCLEUS IN ANGIOTENSIN II-INDUCED WATER INTAKE, NEUROSCIENCE, 2013, 252 pp. 410 - 419
dc.identifier0306-4522
dc.identifierhttp://hdl.handle.net/11343/41845
dc.identifier10.1016/j.neuroscience.2013.08.027
dc.identifier10721
dc.identifier.urihttp://hdl.handle.net/20.500.12424/1990509
dc.description.abstractThe fulltext of this publication will be made publicly available after relevant embargo periods have lapsed and associated copyright clearances obtained.
dc.description.abstractThis study examined which brain regions are influenced by an inhibitory lateral parabrachial nucleus (LPBN) mechanism that affects water intake. Controls and rats with bilateral LPBN lesions were administered angiotensin II (AngII) (0.5mg/kg subcutaneous - SC), drinking responses measured, and brains processed for Fos-immunohistochemistry. A separate group of LPBN-lesioned and non-lesioned animals were denied water for 90 min prior to perfusion to remove any confounding factor of water intake. LPBN-lesioned rats drank a cumulative volume of 9 mL compared with <4 mL by controls (p<0.01). Compared with sham-lesioned animals, Fos expression was attenuated in overdrinking LPBN-lesioned rats in the median preoptic nucleus (MnPO), paraventricular nucleus of the hypothalamus (PVN), supraoptic nucleus (SON) (p<0.001), bed nucleus of the stria terminalis and central nucleus of the amygdala (p<0.01). In LPBN-lesioned rats that did not drink, greater numbers of activated neurons were detected in the PVN (p<0.001), SON (p<0.01), MnPO, nucleus of the solitary tract (NTS) and area postrema (p<0.05) in response to SC AngII, compared with non-lesioned rats. These data suggest that the direct effects of LPBN lesions caused an increase in AngII-induced water intake and in rats that did not drink an increase in Fos expression, while indirect secondary effects of LPBN lesions caused a reduction in Fos expression possibly related to excessive ingestion of water. An inhibitory mechanism, likely related to arterial baroreceptor stimulation, relayed by neurons located in the LPBN influences the responses of the MnPO, PVN and SON to increases in peripheral AngII.
dc.description.abstractOpen Access
dc.languageEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofdoi:10.1016/j.neuroscience.2013.08.027
dc.relation.ispartofissn:0306-4522
dc.relation.ispartofissn:0306-4522
dc.relation.ispartofdoi:10.1016/j.neuroscience.2013.08.027
dc.relation.ispartofNHMRC/454369
dc.subjectparabrachial nucleus
dc.subjectwater intake
dc.subjectFos-immunohistochemistry
dc.subjectangiotensin II
dc.titleBRAIN REGIONS INFLUENCED BY THE LATERAL PARABRACHIAL NUCLEUS IN ANGIOTENSIN II-INDUCED WATER INTAKE
dc.typeJournal Article
ge.collectioncodeOAIDATA
ge.dataimportlabelOAI metadata object
ge.identifier.legacyglobethics:12537954
ge.identifier.permalinkhttps://www.globethics.net/gtl/12537954
ge.lastmodificationdate2018-03-01 00:05
ge.lastmodificationuseradmin@pointsoftware.ch (import)
ge.submissions0
ge.oai.exportid149000
ge.oai.repositoryid2660
ge.oai.setnameFlorey Department of Neuroscience and Mental Health
ge.oai.setnameHealth Sciences
ge.oai.setnameMinerva Access
ge.oai.setnameFlorey Department of Neuroscience and Mental Health - Research Publications
ge.oai.setspeccom_11343_268
ge.oai.setspeccom_11343_163
ge.oai.setspeccom_11343_159
ge.oai.setspeccol_11343_269
ge.oai.streamid5
ge.setnameGlobeTheoLib
ge.setspecglobetheolib
ge.linkhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000325836000036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
ge.linkhttp://hdl.handle.net/11343/41845


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