Statins and bones

Abstract

"S tatins (HMG-CoA reductase inhibitors) have been used for the treatment of hypercholesterolemia and coronary artery disease for more than a decade. Their efficacy and safety have been well documented in a number of large primary and secondary clinical trials.1–4 Their mechanism of action is the inhibition of the rate-limiting enzyme of cholesterol synthesis, namely, HMG-CoA reductase.5 In addition to their well-known cholesterollowering properties, other effects of statins have been noted. These were recently reviewed by Davignon and Laaksonen."