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dc.contributor.authorDiwadkar, Vaibhav A
dc.contributor.authorBellani, Marcella
dc.contributor.authorAhmed, Rizwan
dc.contributor.authorDusi, Nicola
dc.contributor.authorRambaldelli, Gianluca
dc.contributor.authorPerlini, Cinzia
dc.contributor.authorMarinelli, Veronica
dc.contributor.authorRamaseshan, Karthik
dc.contributor.authorRuggeri, Mirella
dc.contributor.authorBambilla, Paolo
dc.date.accessioned2019-10-28T14:51:52Z
dc.date.available2019-10-28T14:51:52Z
dc.date.created2018-09-05 00:37
dc.date.issued2016
dc.identifieroai:iris.univr.it:11562/929284
dc.identifierhttp://hdl.handle.net/11562/929284
dc.identifier10.1016/j.bbr.2015.10.016
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2015.10.016
dc.identifier.urihttp://hdl.handle.net/20.500.12424/2466613
dc.description.abstractINTRODUCTION: The rate of biological change in middle-adulthood is relatively under-studied. Here, we used behavioral testing in conjunction with structural magnetic resonance imaging to examine the effects of chronological age on associative learning proficiency and on brain regions that previous functional MRI studies have closely related to the domain of associative learning.
 METHODS: Participants (n=66) completed a previously established associative learning paradigm, and consented to be scanned using structural magnetic resonance imaging. Age-related effects were investigated both across sub-groups in the sample (younger vs. older) and across the entire sample (using regression approaches).
 RESULTS: Chronological age had substantial effects on learning proficiency (independent of IQ and Education Level), with older adults showing a decrement compared to younger adults. In addition, decreases in estimated gray matter volume were observed in multiple brain regions including the hippocampus and the dorsal prefrontal cortex, both of which are strongly implicated in associative learning.
 CONCLUSION: The results suggest that middle adulthood may be a more dynamic period of life-span change than previously believed. The conjunctive application of narrowly focused tasks, with conjointly acquired structural MRI data may allow us to enrich the search for, and the interpretation of, age-related changes in cross-sectional samples.
 
 Copyright © 2015 Elsevier B.V. All rights reserved.
dc.format.mediumSTAMPA
dc.language.isoeng
dc.relation.ispartofinfo:eu-repo/semantics/altIdentifier/pmid/26462573
dc.relation.ispartofinfo:eu-repo/semantics/altIdentifier/wos/WOS:000367107900040
dc.relation.ispartofinfo:eu-repo/semantics/altIdentifier/hdl/11562/929284
dc.relation.ispartofBEHAVIOURAL BRAIN RESEARCH
dc.relation.ispartofurn:ISSN:0166-4328
dc.subjectaging
dc.subjectassociative learning
dc.subjectbrain structure
dc.subjecthippocampus
dc.subjectlife span changes
dc.subjectvoxel based morphometry
dc.titleChronological age and its impact on associative learning proficiency and brain structure in middle adulthood
dc.typeinfo:eu-repo/semantics/article
ge.collectioncodeOAIDATA
ge.dataimportlabelOAI metadata object
ge.identifier.legacyglobethics:15114050
ge.identifier.permalinkhttps://www.globethics.net/gel/15114050
ge.lastmodificationdate2018-09-05 00:37
ge.lastmodificationuseradmin@pointsoftware.ch (import)
ge.submissions0
ge.oai.exportid149801
ge.oai.repositoryid100033
ge.oai.setname01 Contributo in rivista
ge.oai.setnameSIARI VERONA
ge.oai.setname01.01 Articolo in Rivista
ge.oai.setspeccom_11562_924251
ge.oai.setspeccom_11562_924250
ge.oai.setspeccol_11562_924208
ge.oai.streamid2
ge.setnameGlobeEthicsLib
ge.setspecglobeethicslib
ge.linkhttp://hdl.handle.net/11562/929284
ge.linkhttps://dx.doi.org/10.1016/j.bbr.2015.10.016


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