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AbstractBackground and Objectives: Sleep is a sign of the greatness of God. In this article sleep is described from Quran and modern health sciences. Methods: This is a qualitative systematic review. Data were gathered from the Quran, related Islamic narratives and literatures. Words that were searched included sleep,sleep stages, Subaat, Hojoo, Ruqood, Nu&rsquo;ass, Sinah. Results: The results showed that the Arabic words in the Quran about sleep are Sinah, Nu&rsquo;ass, Hojoo, Ruqood and Subaa. These descriptions about sleep from Quran perspective are consistent with different sleep stages that have been recognized by modern medicine. Conclusion: The Quran and Hadith have described about the types of sleep and the importance and sleeping patterns. In Quran perspective, human is a creature that needs light at day and darkness at night and sleep is an invisible blessing that merciful God gives peace and welfare to his creatures.