Ethical Challenges in Efficacy Trials of Vaginal Microbicides for HIV Prevention
Keywords
AidsAids Serodiagnosis
Clinical Trials
Community Services
Control Groups
Counseling
Clinical Research
Decision Making
Developing Countries
Drugs
Education
Ethical Review
Females
Guidelines
Health
Health Education
Health Promotion
Health Services
Health Services Research
HIV Seropositivity
Human Experimentation
Investigators
Justice
Medicine
Moral Policy
Preventive Medicine
Research
Research Design
Research Subjects
Resource Allocation
Review
Risk
Risks and Benefits
Sexuality
Sexually Transmitted Diseases
Women's Health
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http://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Ethical+Challenges+in+Efficacy+Trials+of+Vaginal+Microbicides+for+Hiv+prevention&title=American+Journal+of+Public+Health.++&volume=88&issue=4&pages=571-575&date=1998&au=de+Zoysa,+Isabellehttp://hdl.handle.net/10822/756215
Abstract
This paper discusses some of the ethical challenges raised by advanced clinical trials designed to assess the safety and efficacy of vaginal microbicides in protecting women from HIV infection. The ethical principles that guide clinical research involving human subjects require that all participants in such trials be provided available measures known to reduce the risk of HIV infection. However, this will reduce the ability of the study to assess the protective effect of the test microbicide. In addition, providing extensive services to trial participants may be construed as an undue inducement if the study is being conducted among vulnerable groups such as sex workers or women from disadvantaged communities. Suggestions are provided to resolve this dilemma in the planning and implementation of HIV prevention services for trial participants.Date
2015-05-05Identifier
oai:repository.library.georgetown.edu:10822/756215American Journal of Public Health. 1998 Apr; 88(4): 571-575.
0090-0036
http://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Ethical+Challenges+in+Efficacy+Trials+of+Vaginal+Microbicides+for+Hiv+prevention&title=American+Journal+of+Public+Health.++&volume=88&issue=4&pages=571-575&date=1998&au=de+Zoysa,+Isabelle
http://hdl.handle.net/10822/756215
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