Showing items related by title, author, creator and subject.

• Privacy-preserving genomic testing in the clinic: A model using HIV treatment

  Mclaren P.J.; Raisaro J.L.; Aouri M.; Rotger M.; Ayday E.; Bartha I.; Delgado M.B.; Vallet Y.; Günthard H.F.; Cavassini M.; et al. (Nature Publishing Group, 2018-04-12)

  Purpose:The implementation of genomic-based medicine is hindered by unresolved questions regarding data privacy and delivery of interpreted results to health-care practitioners. We used DNA-based prediction of HIV-related outcomes as a model to explore critical issues in clinical genomics.Methods:We genotyped 4,149 markers in HIV-positive individuals. Variants allowed for prediction of 17 traits relevant to HIV medical care, inference of patient ancestry, and imputation of human leukocyte antigen (HLA) types. Genetic data were processed under a privacy-preserving framework using homomorphic encryption, and clinical reports describing potentially actionable results were delivered to health-care providers.Results:A total of 230 patients were included in the study. We demonstrated the feasibility of encrypting a large number of genetic markers, inferring patient ancestry, computing monogenic and polygenic trait risks, and reporting results under privacy-preserving conditions. The average execution time of a multimarker test on encrypted data was 865 ms on a standard computer. The proportion of tests returning potentially actionable genetic results ranged from 0 to 54%.Conclusions:The model of implementation presented herein informs on strategies to deliver genomic test results for clinical care. Data encryption to ensure privacy helps to build patient trust, a key requirement on the road to genomic-based medicine. © 2015 American College of Medical Genetics and Genomics.
• Al-Wasf Al-Shar'i Li Al-Jinum Al-Bashari Wa Al-'Ilaj Al-Jini

  Nashmi, 'ajil (2016-01-08)

  This paper was submitted to the symposium held by the Islamic Organization for Medical Sciences (IOMS) in Kuwait during the period 13-15 October 1998 on genetics. The paper starts with introductory notes on the importance of science in building up civilizations. The author views that scientific research on genetics is one of the most important scientific achievements in the modern time. He concludes that the Islamic religio-ethical perspective on the Human Genome Project (HGP) and gene therapy should be developed on the basis of evaluating both their risks and benefits.
• Al-Wirathah Wa Al-Handasah Al-Wirathiyah Wa Al-Jinum Al-Bashari Wa Al-'Ilaj Al-Jini: Ru'yah Islamiyah (Al-Juz' Al-Awwal) Al-Wirathah Wa Al-Handasah Al-Wirathiyah Wa Al-Jinum Al-Bashari Genetics, Genetic Engineering, Human Genome and Genetic Therapy: An Islamic Perspective (Vol. 1) Genetics, Genetic Engineering and the Human Genome

  Jundi, Ahmad Raja'i (2016-01-08)