Sleep after spatial learning promotes covert reorganization of brain activity
Author(s)
Orban, PierreRauchs, Géraldine
Balteau, Evelyne
Degueldre, Christian
Luxen, André
Maquet, Pierre
Peigneux, Philippe
Keywords
PsychologieAdult
Behavior -- physiology
Brain -- anatomy & histology
Brain -- physiology
Female
Humans
Learning -- physiology
Magnetic Resonance Imaging
Male
Nerve Net
Sleep -- physiology
Sleep Deprivation
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https://dipot.ulb.ac.be/dspace/bitstream/2013/26099/1/PMC1459028.pdfhttp://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/26099
Abstract
Sleep promotes the integration of recently acquired spatial memories into cerebral networks for the long term. In this study, we examined how sleep deprivation hinders this consolidation process. Using functional MRI, we mapped regional cerebral activity during place-finding navigation in a virtual town, immediately after learning and 3 days later, in subjects either allowed regular sleep (RS) or totally sleep-deprived (TSD) on the first posttraining night. At immediate and delayed retrieval, place-finding navigation elicited increased brain activity in an extended hippocampo-neocortical network in both RS and TSD subjects. Behavioral performance was equivalent between groups. However, striatal navigation-related activity increased more at delayed retrieval in RS than in TSD subjects. Furthermore, correlations between striatal response and behavioral performance, as well as functional connectivity between the striatum and the hippocampus, were modulated by posttraining sleep. These data suggest that brain activity is restructured during sleep in such a way that navigation in the virtual environment, initially related to a hippocampus-dependent spatial strategy, becomes progressively contingent in part on a response-based strategy mediated by the striatum. Both neural strategies eventually relate to equivalent performance levels, indicating that covert reorganization of brain patterns underlying navigation after sleep is not necessarily accompanied by overt changes in behavior.Journal Article
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published
Date
2006Type
info:eu-repo/semantics/articleIdentifier
oai:dipot.ulb.ac.be:2013/26099uri/info:doi/10.1073/pnas.0510198103
uri/info:pii/0510198103
uri/info:pmid/16636288
uri/info:pmcid/PMC1459028
local/pp-0002
https://dipot.ulb.ac.be/dspace/bitstream/2013/26099/1/PMC1459028.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/26099