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dc.contributor.authorSarkaki, Alireza
dc.contributor.authorRezaiei, Moslem
dc.contributor.authorNaseri, MohammadKazem Gharib
dc.contributor.authorRad, Maryam Rafiei
dc.date.accessioned2019-10-24T08:37:48Z
dc.date.available2019-10-24T08:37:48Z
dc.date.created2017-02-28 00:10
dc.date.issued2013-04-02
dc.identifieroai:cria:bioline:mj:mj13020
dc.identifierhttp://www.bioline.org.br/abstract?id=mj13020
dc.identifier.urihttp://hdl.handle.net/20.500.12424/915098
dc.description.abstractBackground: This study aimed to evaluate the effect of two weeks oral administration of pomegranate seed extract (PGSE) on active and passive avoidance memories after permanent bilateral common carotid arteries occlusion (2CCAO) to induce permanent cerebral ischemia in adult female rats. Methods: Seventy adult female Wistar rats (250 ± 20 g) were used. Animals were divided randomly into seven groups with 10 in each: 1) Sham-operated; 2) Ischemic; 3–6) Ischemic received PGSE (100, 200, 400, and 800 mg/2mL/kg, orally) for 14 days; 7) Ischemic received vehicle. In order to create 2CCAO, carotid arteries were ligatured and then cut bilaterally. Active and passive avoidance task were measured using criterion condition responses (CCRs) in Y-maze and step-through latency (STL) in two-way shuttle box in all female rats. Results: Both active and passive avoidance memories were significantly impaired in rats after cerebral hypoxia-ischemia (CHI) (P < 0.001). PGSE treatment significantly improved passive and active memory impairments with 2CCAO (P < 0.05, P < 0.01, and P < 0.001). No toxicity was observed even with high-dose PGSE consumption (800 mg/kg, for 14 days). Conclusion: PGSE exhibits therapeutic potential for avoidance memories, which is most likely related at least in part to its antioxidative and free radical scavenging actions.
dc.format.mediumhtml
dc.languageen
dc.language.isoeng
dc.publisherSchool of Medical Sciences, Universiti Sains Malaysia
dc.relation.ispartofhttp://www.medic.usm.my/publication/mjms/; http://www.bioline.org.br/mj
dc.rightsCopyright 2013 - Malaysian Journal of Medical Sciences
dc.sourceMalaysian Journal of Medical Sciences (ISSN: 1394-195X) Vol 20 Num 2
dc.subjectcerebral ischemia, pomegranate, memory, female, rats
dc.titleImproving Active and Passive Avoidance Memories Deficits Due to Permanent Cerebral Ischemia by Pomegranate Seed Extract in Female Rats
dc.typeAA
ge.collectioncodeOAIDATA
ge.dataimportlabelOAI metadata object
ge.identifier.legacyglobethics:10527821
ge.identifier.permalinkhttps://www.globethics.net/gtl/10527821
ge.lastmodificationdate2017-02-28 00:10
ge.lastmodificationuseradmin@pointsoftware.ch (import)
ge.submissions0
ge.oai.exportid149000
ge.oai.repositoryid553
ge.oai.setnameMalaysian Journal of Medical Sciences
ge.oai.setspecmj
ge.oai.streamid5
ge.setnameGlobeTheoLib
ge.setspecglobetheolib
ge.linkhttp://www.bioline.org.br/abstract?id=mj13020


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