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dc.contributorThe Pennsylvania State University CiteSeerX Archives
dc.contributor.authorInflammatory Pain
dc.contributor.authorYi Liang
dc.contributor.authorJian-Qiao Fang
dc.contributor.authorJun-Ying Du
dc.contributor.authorJun-Fan Fang
dc.date.accessioned2019-10-24T09:29:02Z
dc.date.available2019-10-24T09:29:02Z
dc.date.created2017-02-28 00:15
dc.date.issued2013-07-10
dc.identifieroai:CiteSeerX.psu:10.1.1.289.2511
dc.identifierhttp://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.2511
dc.identifier.urihttp://hdl.handle.net/20.500.12424/924782
dc.description.abstractpermits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Activation of mitogen-activated protein kinases (MAPKs), especially p38 MAPK, plays an important role in the development of central sensitization related to persistent inflammatory pain. Electroacupuncture (EA) is well known to relieve persistent inflammatory pain. However, little is known about relationship between EA and p38 MAPK. Inflammatory pain rat model was induced by intraplantar injection of complete Freund’s adjuvant (CFA). Male adult SD rats were randomly divided into the saline group, CFA group, and CFA + EA group. EA (constant saquare wave, 2 Hz and 100 Hz alternating frequencies, intensities ranging from 1 to 2 mA) was applied to bilateral “Zusanli ” (ST 36) and “Kunlun ” acupoints (BL 60) for 30 min, once per day. The paw edema and paw withdrawal threshold (PWT) were measured at preinjection and days postinjection 1, 3, and 14. Spinal p-p38MAPK- immunoreactivty (p-p38MAPK-IR) cells were detected by immunohistochemistry at postinjection day 3 and 14. EA significantly inhibited paw edema at postinjection days 14 and increased PWT at postinjection days 3 and 14. Moreover, the increasing number of spinal p-p38MAPK-IR cells which was induced by CFA injection was suppressed by EA stimulation. These results indicate that anti-inflammatory and analgesic effect of EA might be associated with its inhibition of spinal p38 MAPK activation and thereby provide a potential mechanism for the treatment of inflammatory pain by EA. 1.
dc.format.mediumapplication/zip
dc.languageen
dc.language.isoeng
dc.rightsMetadata may be used without restrictions as long as the oai identifier remains attached to it.
dc.titleResearch Article Effect of Electroacupuncture on Activation of p38MAPK in Spinal Dorsal Horn in Rats with Complete
dc.typetext
ge.collectioncodeOAIDATA
ge.dataimportlabelOAI metadata object
ge.identifier.legacyglobethics:10537818
ge.identifier.permalinkhttps://www.globethics.net/gtl/10537818
ge.lastmodificationdate2017-02-28 00:15
ge.lastmodificationuseradmin@pointsoftware.ch (import)
ge.submissions0
ge.oai.exportid149000
ge.oai.repositoryid54
ge.oai.streamid5
ge.setnameGlobeTheoLib
ge.setspecglobetheolib
ge.linkhttp://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.2511
ge.linkftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e5/96/Evid_Based_Complement_Alternat_Med_2012_Aug_8_2012_568273.tar.gz


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