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dc.contributor.authorAaron Ciechanover
dc.date.accessioned2019-10-24T16:52:21Z
dc.date.available2019-10-24T16:52:21Z
dc.date.created2017-02-28 01:02
dc.date.issued2012-01-01
dc.identifieroai:doaj.org/article:72e370227c5c443597878cebc2ac1448
dc.identifier10.5041/RMMJ.10068
dc.identifier2076-9172
dc.identifierhttps://doaj.org/article/72e370227c5c443597878cebc2ac1448
dc.identifier.urihttp://hdl.handle.net/20.500.12424/992717
dc.description.abstractBetween the 1950s and 1980s, scientists were focusing mostly on how the genetic code was transcribed to RNA and translated to proteins, but how proteins were degraded had remained a neglected research area. With the discovery of the lysosome by Christian de Duve it was assumed that cellular proteins are degraded within this organelle. Yet, several independent lines of experimental evidence strongly suggested that intracellular proteolysis was largely non-lysosomal, but the mechanisms involved have remained obscure. The discovery of the ubiquitin-proteasome system resolved the enigma. We now recognize that degradation of intracellular proteins is involved in regulation of a broad array of cellular processes, such as cell cycle and division, regulation of transcription factors, and assurance of the cellular quality control. Not surprisingly, aberrations in the system have been implicated in the pathogenesis of human disease, such as malignancies and neurodegenerative disorders, which led subsequently to an increasing effort to develop mechanism-based drugs.
dc.publisherRambam Health Care Campus
dc.relation.ispartofhttp://rmmj.org.il/(S(oxljzzxknrkw35nthmabksny))/Pages/ArticleHTM.aspx?manuId=140
dc.relation.ispartofhttps://doaj.org/toc/2076-9172
dc.rightsCC BY
dc.sourceRambam Maimonides Medical Journal, Vol 3, Iss 1, p e0001 (2012)
dc.subjectUbiquitin
dc.subjectproteasome
dc.subjectprotein degradation
dc.subjectlysosome
dc.subjectdiseases
dc.subjectMedicine
dc.subjectR
dc.subjectMedicine (General)
dc.subjectR5-920
dc.titleIntracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting
dc.typeArticle
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ge.identifier.permalinkhttps://www.globethics.net/gtl/10623469
ge.lastmodificationdate2017-02-28 01:02
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