Bernabe, Rosemarie D L Cvan Thiel, Ghislaine J M WRaaijmakers, Jan A M2019-09-252019-09-252015-08-2120121472-6939http://hdl.handle.net/20.500.12424/226046"Background Research ethics committees (RECs) are tasked to assess the risks and the benefits of a trial. Currently, two procedure-level approaches are predominant, the Net Risk Test and the Component Analysis. Discussion By looking at decision studies, we see that both procedure-level approaches conflate the various risk-benefit tasks, i.e., risk-benefit assessment, risk-benefit evaluation, risk treatment, and decision making. This conflation makes the RECs’ risk-benefit task confusing, if not impossible. We further realize that RECs are not meant to do all the risk-benefit tasks; instead, RECs are meant to evaluate risks and benefits, appraise risk treatment suggestions, and make the final decision. Conclusion As such, research ethics would benefit from looking beyond the procedure-level approaches and allowing disciplines like decision studies to be involved in the discourse on RECs’ risk-benefit task"engCreative Commons Copyright (CC 2.5)Component analysisNet risk testDecision theoryIRBEthics committeeRisk benefit assessmentMethods of ethicsBioethicsMedical ethicsArticle